Ntrk1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comNtrk1 CLIA Kit for Rat(Rattus norvegicus)

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Ntrk1 (Gene name),

High affinity nerve growth factor receptor (Protein name ), NTRK1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ntrk1(Trk;Trka);

Protein name:

High affinity nerve growth factor receptor;

Alternative:

Slow nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;p140-TrkA(Trk-A);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and KIDINS220. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.

Function:

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Endocytosed to the endosomes upon treatment of cells with NGF.

Protein Attributes:

Sequence length:

799

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

799:

RPRACPPDVY | AIMRGCWQRE | PQQRLSMKDV | HARLQALAQA | PPSYLDVLG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P35739

Pfam:

PF07714

UniGene:

Rn.39098

SMR:

P35739

KEGG:

rno:59109

Uniprot:

P35739

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ELISA Kit for Rat High affinity nerve growth factor receptor

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E9557h

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96T

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ELISA Kit for Rat High affinity nerve growth factor receptor

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E9557m

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96T

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ELISA Kit for Rat High affinity nerve growth factor receptor

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ELISA Kit for Rat High affinity nerve growth factor receptor

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E9557r

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CLIA Kit for Rat High affinity nerve growth factor receptor

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CLIA Kit for Rat High affinity nerve growth factor receptor

Cat.:

U9557r

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MSDS:

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Packing:

96T

CLIA Kit for Rat High affinity nerve growth factor receptor

Cat.:

U9557m

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MSDS:

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Packing:

96T

CLIA Kit for Rat High affinity nerve growth factor receptor

Cat.:

U9557h

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96T

Polyclonal Antibody for Rat High affinity nerve growth factor receptor

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P9557Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat High affinity nerve growth factor receptor

Cat.:

P9557Rb-m

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Packing:

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Polyclonal Antibody for Rat High affinity nerve growth factor receptor

Monoclonal Antibody for Rat High affinity nerve growth factor receptor

Protein for Rat High affinity nerve growth factor receptor

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor."
Meakin S.O. , Suter U. , Drinkwater C.C. , Welcher A.A. , Shooter E.M.
Proc. Natl. Acad. Sci. U.S.A.89:2374-2378(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKA-II)
2.

"Tissue-specific alternative splicing generates two isoforms of the trkA receptor."
Barker P.A. , Lomen-Hoerth C. , Gensch E.M. , Meakin S.O. , Glass D.J. , Shooter E.M.
J. Biol. Chem.268:15150-15157(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS TRKA-I AND TRKA-II)
3.

"Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses."
Stephens R.M. , Loeb D.M. , Copeland T.D. , Pawson T. , Greene L.A. , Kaplan D.R.
Neuron12:691-705(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHC1
4.

"Identification and characterization of novel substrates of Trk receptors in developing neurons."
Qian X. , Riccio A. , Zhang Y. , Ginty D.D.
Neuron21:1017-1029(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCG1; SHC1; SH2B1 AND SH2B2;MUTAGENESIS OF VAL-527
5.

"The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."
Wooten M.W. , Seibenhener M.L. , Mamidipudi V. , Diaz-Meco M.T. , Barker P.A. , Moscat J.
J. Biol. Chem.276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1
6.

"An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors."
Kong H. , Boulter J. , Weber J.L. , Lai C. , Chao M.V.
J. Neurosci.21:176-185(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIDINS220
7.

"Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling."
Geetha T. , Wooten M.W.
J. Biol. Chem.278:4730-4739(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1;SUBCELLULAR LOCATION;DOMAIN
8.

"A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein."
Arevalo J.C. , Yano H. , Teng K.K. , Chao M.V.
EMBO J.23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIDINS220;DOMAIN
9.

"Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein."
Chang M.-S. , Arevalo J.C. , Chao M.V.
J. Neurosci. Res.78:186-192(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGFR AND KIDINS220;DOMAIN
10.

"SLAM-associated protein as a potential negative regulator in Trk signaling."
Lo K.Y. , Chin W.H. , Ng Y.P. , Cheng A.W. , Cheung Z.H. , Ip N.Y.
J. Biol. Chem.280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH SH2D1A
11.

"The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA."
Saxena S. , Bucci C. , Weis J. , Kruttgen A.
J. Neurosci.25:10930-10940(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB7A
12.

"Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
Hisata S. , Sakisaka T. , Baba T. , Yamada T. , Aoki K. , Matsuda M. , Takai Y.
J. Cell Biol.178:843-860(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH KIDINS220; MAGI2 AND RAPGEF2;INTERACTION WITH RAPGEF2;SUBCELLULAR LOCATION
13.

"Neurotrophin receptor homolog-2 regulates nerve growth factor signaling."
Wong A.W. , Willingham M. , Xiao J. , Kilpatrick T.J. , Murray S.S.
J. Neurochem.106:1964-1976(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRADD
14.

"Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not."
Nikoletopoulou V. , Lickert H. , Frade J.M. , Rencurel C. , Giallonardo P. , Zhang L. , Bibel M. , Barde Y.A.
Nature467:59-63(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL DEATH

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